Basic Blue Skies Research in the UK: Are we losing out?

Lifted from....Belinda Linden


http://www.j-biomed-discovery.com/content/3/1/3 accessed 10 Jun 2011.


The term "blue skies research" derives from Julius Comroe, who explained in 1976 how scientific discoveries often arise from tortuous curiosity-driven paths, rather than a direct goal-driven route [11]. He used as his example an event where Charles Wilson, President Eisenhower's Secretary of Defence and an opponent of basic research, said: "I don't care what makes the grass green!" Comroe claimed that Wilson might just as well have said, "I don't care what makes the sky blue!" Comroe defended the need for basic research by describing the work of a British physicist called John Tyndall whose research in 1869 explained the blue colour of the sky by using a glass tube into which he introduced certain vapours. When illuminated, the tube filled with many fine particles. When a powerful beam of light focused on the tube in a dark room, a sky blue cloud filled the tube [12]. Comroe describes how through this discovery, Tyndall's work explained many other unrelated concepts. His examples included the development of a test for optically pure air that was unable to develop bacteria, success in convincing scientists of Pasteur's claim that there was no such thing as spontaneous generation, research demonstrating how lung airways remove particles from inspired air before reaching the alveoli. Tyndall also discovered 50 years before Fleming how penicillium bacteria could successfully destroy a mould [13]. He showed how a light beam followed a curved route, leading to the later development of the flexible gastroscope and bronchoscope [14]. Tyndall's work therefore provided strong evidence to show that important discoveries are often curiosity-led rather than goal-driven. Comroe asked US cardiologists to list the professional activities that they considered to be the most valuable. When the origins of these advances were examined, he demonstrated that more than 70% of the clinical tools used by cardiologists arose from fundamental, curiosity-driven research performed without a cardiological outcome in mind. This report was used as a key argument to convince the US Congress that basic blue skies research had a better than average chance of translating into something clinically useful compared to that derived from problem-oriented research [24].